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Amy Klobuchar (D Minn.) said she is concerned the United States needs to be focused on the bigger picture and look at the “monopoly issues of our time.” European regulators have been much more active on antitrust in the tech sector, and have brought major fines against American companies like Google.The senators tough questions come after they loudly criticized recent government actions against Big Tech, particularly the FTC’s attempts to fine the companies for privacy. Both Blumenthal and Hawley pressed the officials on their recent $5 billion fine against Facebook, which was widely criticized as a slap on a wrist.BITS: Facebook finally unveiled its blueprint for an independent oversight board that will review the company’s decisions over what content it chooses to remove, my colleague Tony Romm reports. The new Supreme Court like panel could offer insight into the company’s often opaque decisions about what constitutes harmful speech and potentially allow top executives and engineers to deflect criticism, Tony writes.The charter released yesterday outlines the oversight board will have around 40 members from around the world, each serving three year terms.

NASCAR banned the flag at its races and all its venues Wednesday, a dramatic if overdue step by a series steeped in Southern tradition and proud of its good ol boy roots. It must now hope to convince some of its most ardent fans that it is truly time to leave the flag at home, leave those T shirts in the drawer, scrape off the bumper stickers and hit the track without a trace of the longtime symbol to many of racism and slavery. Policing the policy may prove challenging and NASCAR did not offer details..

London based Eye Respect takes its design philosophy from Baldassare Castiglione 16th century concept of sprezzatura, which has come to mean a relaxed elegance. Handcrafted by a family run business in Veneto, the sunglasses are characteristically bold, incorporating the nuances of tortoiseshell acetate. Frame goes through more than 60 crafted stages to achieve the style and quality we respect, represent and embrace, says chief executive Jonathan van Blerk.

Do you want to get away from the hustle and bustle of the city? Pleasant Streams Farm, in St. Austell, Cornwall, offers a serene and quiet environment. The peaceful and child friendly site is just the right place to get enough rest. Muscle atrophy is a feature of many chronic diseases and contributes to both morbidity and mortality, emphasising the importance of understanding the molecular pathways involved. Zinc finger protein 216 (ZNF216) is an atrogene, a gene which is up regulated during and directly mediates skeletal muscle atrophy, and encodes the ubiquitin (Ub) receptor protein ZNF216. Herein it is demonstrated that ZNF216 mRNA levels increase in the extensor digitorum longus (EDL) in a lipopolysaccharide (LPS) infusion rat model of muscle atrophy, relative to saline control.

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