The findings emerged from this thesis have important implications for the theoretical development of institutional changes, sensemaking and especially deinstitutionalisation. First of all, the model and evidence sheds some light on the nature and development of the deinstitutionalisation process. Secondly, the analytic capacity of the institutional theory especially its descriptive and predictive contents are tested in the context of evolving institutions.
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Therefore, 11 HSD1 could modulate the impact of GCs on BAT function. This study investigated how 11 HSD1 regulates the molecular architecture of BAT in the context of GC excess and aging. Circulating GC excess was induced in 11 HSD1 knockout (KO) and wild type mice by supplementing drinking water with 100 g/mL corticosterone, and the effects on molecular markers of BAT function and mitochondrial activity were assessed.
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